Histamine type 1 receptor blockers include diphenhydramine and loratadine and can help with symptoms like itching and stomach pain. These block the effects of histamines, which are one of the primary mediators that mast cells release. Treating your symptoms can also help you find triggers that cause your MCAS episodes. MCAS doesn’t have a cure, but there are ways to manage symptoms. Since you may respond to certain foods differently than other people, it’s important to talk with your doctor or dietitian to find a nutritious diet that will work best for you.